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Publications

Mouse genome rewriting and tailoring of three important disease loci.

Zhang W, Golynker I, Brosh R, Fajardo A, Zhu Y, Wudzinska AM, Ordoñez R, Ribeiro-Dos-Santos AM, Carrau L, Damani-Yokota P, Yeung ST, Khairallah C, Vela Gartner A, Chalhoub N, Huang E, Ashe HJ, Khanna KM, Maurano MT, Kim SY, tenOever BR, Boeke JD.Nature. 2023 Nov;623(7986):423-431. doi: 10.1038/s41586-023-06675-4. Epub 2023 Nov 1.PMID: 37914927 

Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19.

Kusakabe T, Lin WY, Cheong JG, Singh G, Ravishankar A, Yeung ST, Mesko M, DeCelie MB, Carriche G, Zhao Z, Rand S, Doron I, Putzel GG, Worgall S, Cushing M, Westblade L, Inghirami G, Parkhurst CN, Guo CJ, Schotsaert M, García-Sastre A, Josefowicz SZ, Salvatore M, Iliev ID.Nat Immunol. 2023 Nov;24(11):1879-1889. doi: 10.1038/s41590-023-01637-4. Epub 2023 Oct 23.PMID: 37872315

MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation.

Noval MG, Spector SN, Bartnicki E, Izzo F, Narula N, Yeung ST, Damani-Yokota P, Dewan MZ, Mezzano V, Rodriguez-Rodriguez BA, Loomis C, Khanna KM, Stapleford KA.Nat Commun. 2023 Aug 3;14(1):4668. doi: 10.1038/s41467-023-40047-w.PMID: 37537212 

Elevated Galectin-9 across the human brain correlates with HIV neuropathology and detrimental cognitive states.

Premeaux TA*, Yeung ST*, Pillai SK, Ndhlovu LC.J Neurovirol. 2023 Jun;29(3):337-345. doi: 10.1007/s13365-023-01149-9. Epub 2023 May 26.PMID: 37233903 *Co-First Author.

A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8.

Rodriguez-Rodriguez BA, Ciabattoni GO, Duerr R, Valero-Jimenez AM, Yeung ST, Crosse KM, Schinlever AR, Bernard-Raichon L, Rodriguez Galvan J, McGrath ME, Vashee S, Xue Y, Loomis CA, Khanna KM, Cadwell K, Desvignes L, Frieman MB, Ortigoza MB, Dittmann M.Nat Commun. 2023 May 25;14(1):3026. doi: 10.1038/s41467-023-38783-0.PMID: 37230979

Human galectin-9 potently enhances SARS-CoV-2 replication and inflammation in airway epithelial cells.

Du L, Bouzidi MS, Gala A, Deiter F, Billaud JN, Yeung ST, Dabral P, Jin J, Simmons G, Dossani ZY, Niki T, Ndhlovu LC, Greenland JR, Pillai SK.J Mol Cell Biol. 2023 Aug 3;15(4):mjad030. doi: 10.1093/jmcb/mjad030.PMID: 37127426 

Age-dependent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogens.

Bee GCW, Lokken-Toyli KL, Yeung ST, Rodriguez L, Zangari T, Anderson EE, Ghosh S, Rothlin CV, Brodin P, Khanna KM, Weiser JN.Immunity. 2023 Apr 5:S1074-7613(23)00138-3. doi: 10.1016/j.immuni.2023.03.018. Online ahead of print.PMID: 37059107

CD169+ macrophage intrinsic IL-10 production regulates immune homeostasis during sepsis.

Yeung ST, Ovando LJ, Russo AJ, Rathinam VA, Khanna KM.Cell Rep. 2023 Mar 28;42(3):112171. doi: 10.1016/j.celrep.2023.112171. Epub 2023 Mar 2.PMID: 36867536 

A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8.

Rodriguez-Rodriguez BA, Ciabattoni GO, Valero-Jimenez AM, Crosse KM, Schinlever AR, Galvan JJR, Duerr R, Yeung ST, McGrath ME, Loomis C, Khanna KM, Desvignes L, Frieman MF, Ortigoza MB, Dittmann M. bioRxiv. 2022 Oct 24:2022.10.04.510658. doi: 10.1101/2022.10.04.510658. Preprint.PMID: 36238716 

Galectin-9 protects humanized-ACE2 immunocompetent mice from SARS-CoV-2 infection.

Yeung ST, Premeaux TA, Du L, Niki T, Pillai SK, Khanna KM, Ndhlovu LC. Front Immunol. 2022 Oct 17;13:1011185. doi: 10.3389/fimmu.2022.1011185. eCollection 2022.PMID: 36325323

Human Galectin-9 Potently Enhances SARS-CoV-2 Replication and Inflammation in Airway Epithelial Cells.

Du L, Bouzidi MS, Gala A, Deiter F, Billaud JN, Yeung ST, Dabral P, Jin J, Simmons G, Dossani Z, Niki T, Ndhlovu LC, Greenland JR, Pillai SK.bioRxiv. 2022 Mar 29:2022.03.18.484956. doi: 10.1101/2022.03.18.484956. Preprint.PMID: 35378763

SARS-CoV-2 Spike Mutations Important for Infection of Mice and Escape from Human Immune Sera.

Rathnasinghe R, Jangra S, Ye C, Cupic A, Singh G, Martinez-Romero C, Mulder LCF, Kehrer T, Yildiz S, Choi A, Yeung ST, Mena I, Gillespie V, Vrieze JD, Aslam S, Stadlbauer D, Meekins DA, McDowell CD, Balaraman V, Corley MJ, Richt JA, De Geest BG, Miorin L, PVI study group, Krammer F, Martinez-Sobrido L, Simon V, Garcia-Sastre A, Schotsaert M. Nature Communication. Accepted. (2022)

 

Emerging Insights on Caspases in COVID-19 Pathogenesis, Sequelae, and Directed Therapies.

Premeaux TA, Yeung ST, Bukhari Z, Bowler S, Alpan O, Gupta R, Ndhlovu LC.Front Immunol. 2022 Feb 21;13:842740. doi: 10.3389/fimmu.2022.842740. eCollection 2022.PMID: 35265086

 

Monitoring Circulating Immune Checkpoint Proteins as Predictors of Non-AIDS Morbid Events in People With HIV Initiating Antiretroviral Therapy.

Premeaux TA, Moser CB, McKhann A, Hoenigl M, Yeung ST, Pang APS, Corley MJ, Lederman MM, Landay AL, Gianella S, Ndhlovu LC.Open Forum Infect Dis. 2022 Jan 21;9(3):ofab570. doi: 10.1093/ofid/ofab570. eCollection 2022 Mar.PMID: 35146038

 

Transgender Equity in the Workplace: A Systematic Review.

Davis NB and Yeung ST. Journal of Workplace Rights. (2022).

 

Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome.

Sulaiman I, Chung M, Angel L, Tsay JJ, Wu BG, Yeung ST, Krolikowski K, Li Y, Duerr R, Schluger R, Thannickal SA, Koide A, Rafeq S, Barnett C, Postelnicu R, Wang C, Banakis S, Pérez-Pérez L, Shen G, Jour G, Meyn P, Carpenito J, Liu X, Ji K, Collazo D, Labarbiera A, Amoroso N, Brosnahan S, Mukherjee V, Kaufman D, Bakker J, Lubinsky A, Pradhan D, Sterman DH, Weiden M, Heguy A, Evans L, Uyeki TM, Clemente JC, de Wit E, Schmidt AM, Shopsin B, Desvignes L, Wang C, Li H, Zhang B, Forst CV, Koide S, Stapleford KA, Khanna KM, Ghedin E, Segal LN.Nat Microbiol. 2021 Oct;6(10):1245-1258. doi: 10.1038/s41564-021-00961-5. Epub 2021 Aug 31.PMID: 34465900 

Beyond neutralization for BNT162b2 mRNA vaccination. 

Damani-Yokota P, Yeung ST, Khanna KM.Cell Host Microbe. 2021 Jul 14;29(7):1033-1035. doi: 10.1016/j.chom.2021.06.013.PMID: 34265240

SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2. 

Lu Q, Liu J, Zhao S, Gomez Castro MF, Laurent-Rolle M, Dong J, Ran X, Damani-Yokota P, Tang H, Karakousi T, Son J, Kaczmarek ME, Zhang Z, Yeung ST, McCune BT, Chen RE, Tang F, Ren X, Chen X, Hsu JCC, Teplova M, Huang B, Deng H, Long Z, Mudianto T, Jin S, Lin P, Du J, Zang R, Su TT, Herrera A, Zhou M, Yan R, Cui J, Zhu J, Zhou Q, Wang T, Ma J, Koralov SB, Zhang Z, Aifantis I, Segal LN, Diamond MS, Khanna KM, Stapleford KA, Cresswell P, Liu Y, Ding S, Xie Q, Wang J. Immunity. 2021 Jun 8;54(6):1304-1319.e9. doi: 10.1016/j.immuni.2021.05.006. Epub 2021 May 9.PMID: 34048708 

Caspases and therapeutic potential of caspase inhibitors in moderate-severe SARS CoV2 infection and long COVID.

Plassmeyer M, Alpan O, Corley MJ, Premeaux TA, Lillard K, Coatney P, Vaziri T, Michalsky S, Pang APS, Bukhari Z, Yeung ST, Evering TH, Naughton G, Latterich M, Mudd P, Spada A, Rindone N, Loizou D, Ulrik Sønder S, Ndhlovu LC, Gupta R. Allergy. 2021 May 15:10.1111/all.14907. doi: 10.1111/all.14907. Online ahead of print.PMID: 33993490

TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming.

Barbet G, Nair-Gupta P, Schotsaert M, Yeung ST, Moretti J, Seyffer F, Metreveli G, Gardner T, Choi A, Tortorella D, Tampé R, Khanna KM, García-Sastre A, Blander JM. Nat Immunol. 2021 Apr;22(4):497-509. doi: 10.1038/s41590-021-00903-7. Epub 2021 Mar 31.PMID: 33790474

Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19.

Corley MJ, Pang APS, Dody K, Mudd PA, Patterson BK, Seethamraju H, Bram Y, Peluso MJ, Torres L, Iyer NS, Premeaux TA, Yeung ST, Chandar V, Borczuk A, Schwartz RE, Henrich TJ, Deeks SG, Sacha JB, Ndhlovu LC.J Leukoc Biol. 2021 Jan 19. doi: 10.1002/JLB.5HI0720-466R. Online ahead of print.PMID: 33464637

Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease.

Lee JY, Hall JA, Kroehling L, Wu L, Najar T, Nguyen HH, Lin WY, Yeung ST, Silva HM, Li D, Hine A, Loke P, Hudesman D, Martin JC, Kenigsberg E, Merad M, Khanna KM, Littman DR.Cell. 2020 Dec 23;183(7):2036-2039. doi: 10.1016/j.cell.2020.12.008.PMID: 33357400 No abstract available.

Identification of a nerve-associated, lung-resident interstitial macrophage subset with distinct localization and immunoregulatory properties.

Ural BB*, Yeung ST*, Damani-Yokota P, Devlin JC, de Vries M, Vera-Licona P, Samji T, Sawai CM, Jang G, Perez OA, Pham Q, Maher L, Loke P, Dittmann M, Reizis B, Khanna KM.Sci Immunol. 2020 Mar 27;5(45):eaax8756. doi: 10.1126/sciimmunol.aax8756.PMID: 32220976

The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation.

Guillamot M, Ouazia D, Dolgalev I, Yeung ST, Kourtis N, Dai Y, Corrigan K, Zea-Redondo L, Saraf A, Florens L, Washburn MP, Tikhonova AN, Malumbres M, Gong Y, Tsirigos A, Park C, Barbieri C, Khanna KM, Busino L, Aifantis I.Nat Immunol. 2019 Sep;20(9):1196-1207. doi: 10.1038/s41590-019-0454-6. Epub 2019 Aug 12.PMID: 31406379 

Systemic TLR2 tolerance enhances central nervous system remyelination.

Wasko NJ, Kulak MH, Paul D, Nicaise AM, Yeung ST, Nichols FC, Khanna KM, Crocker S, Pachter JS, Clark RB.J Neuroinflammation. 2019 Jul 27;16(1):158. doi: 10.1186/s12974-019-1540-2.PMID: 31351476 

Single-cell analysis of fate-mapped macrophages reveals heterogeneity, including stem-like properties, during atherosclerosis progression and regression.

Lin JD, Nishi H, Poles J, Niu X, Mccauley C, Rahman K, Brown EJ, Yeung ST, Vozhilla N, Weinstock A, Ramsey SA, Fisher EA, Loke P.JCI Insight. 2019 Feb 21;4(4):e124574. doi: 10.1172/jci.insight.124574. eCollection 2019 Feb 21.PMID: 30830865 

Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice.

Lubkin A, Lee WL, Alonzo F 3rd, Wang C, Aligo J, Keller M, Girgis NM, Reyes-Robles T, Chan R, O'Malley A, Buckley P, Vozhilla N, Vasquez MT, Su J, Sugiyama M, Yeung ST, Coffre M, Bajwa S, Chen E, Martin P, Kim SY, Loomis C, Worthen GS, Shopsin B, Khanna KM, Weinstock D, Lynch AS, Koralov SB, Loke P, Cadwell K, Torres VJ.Cell Host Microbe. 2019 Mar 13;25(3):463-470.e9. doi: 10.1016/j.chom.2019.01.015. Epub 2019 Feb 21.PMID: 30799265

Combination Immunotherapy: Taking Cancer Vaccines to the Next Level.

Grenier JM, Yeung ST, Khanna KM.Front Immunol. 2018 Mar 22;9:610. doi: 10.3389/fimmu.2018.00610. eCollection 2018.PMID: 29623082 

Combining Adoptive Cell Therapy with Cytomegalovirus-Based Vaccine Is Protective against Solid Skin Tumors.

Grenier JM, Yeung ST, Qiu Z, Jellison ER, Khanna KM.Front Immunol. 2018 Jan 16;8:1993. doi: 10.3389/fimmu.2017.01993. eCollection 2017.PMID: 29387061 

CD169+ Macrophages Restrain Systemic Inflammation Induced by Staphylococcus aureus Enterotoxin A Lung Response.

Svedova J, Menoret A, Yeung ST, Tanaka M, Khanna KM, Vella AT. ImmunoHorizons November 1, 2017, 1 (9) 213-222; DOI: https://doi.org/10.4049/immunohorizons.1700033

CD169+ macrophages orchestrate innate immune responses by regulating bacterial localization in the spleen.

Perez OA, Yeung ST, Vera-Licona P, Romagnoli PA, Samji T, Ural BB, Maher L, Tanaka M, Khanna KM.Sci Immunol. 2017 Oct 6;2(16):eaah5520. doi: 10.1126/sciimmunol.aah5520.PMID: 28986418

HuCNS-SC Human NSCs Fail to Differentiate, Form Ectopic Clusters, and Provide No Cognitive Benefits in a Transgenic Model of Alzheimer's Disease.

Marsh SE, Yeung ST, Torres M, Lau L, Davis JL, Monuki ES, Poon WW, Blurton-Jones M.Stem Cell Reports. 2017 Feb 14;8(2):235-248. doi: 10.1016/j.stemcr.2016.12.019.PMID: 28199828

Reduction of central neuropathic pain with ketamine infusion in a patient with Ehlers-Danlos syndrome: a case report.

Yeung ST*, Lo TC*, Lee S, Skavinski K, Liao S.J Pain Res. 2016 Sep 15;9:683-687. doi: 10.2147/JPR.S110261. eCollection 2016.PMID: 27695362 

Increased tauopathy drives microglia-mediated clearance of beta-amyloid.

Chen W, Abud EA, Yeung ST, Lakatos A, Nassi T, Wang J, Blum D, Buée L, Poon WW, Blurton-Jones M.Acta Neuropathol Commun. 2016 Jun 23;4(1):63. doi: 10.1186/s40478-016-0336-1.PMID: 27339073

The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function.

Marsh SE, Abud EM, Lakatos A, Karimzadeh A, Yeung ST, Davtyan H, Fote GM, Lau L, Weinger JG, Lane TE, Inlay MA, Poon WW, Blurton-Jones M.Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1316-25. doi: 10.1073/pnas.1525466113. Epub 2016 Feb 16.PMID: 26884167

Hematuria following Botox treatment for upper limb spasticity: a case report.

Yeung ST*, Lo TC*, Lee S, Chang EY.J Pain Res. 2015 Sep 14;8:619-22. doi: 10.2147/JPR.S88658. eCollection 2015.PMID: 26396542

Repeated cognitive stimulation alleviates memory impairments in an Alzheimer's disease mouse model.

Yeung ST*, Martinez-Coria H*, Ager RR, Rodriguez-Ortiz CJ, Baglietto-Vargas D, LaFerla FM.Brain Res Bull. 2015 Aug;117:10-5. doi: 10.1016/j.brainresbull.2015.07.001. Epub 2015 Jul 7.PMID: 26162480

Hippocampal adaptive response following extensive neuronal loss in an inducible transgenic mouse model.

Yeung ST*, Myczek K*, Castello N, Baglietto-Vargas D, LaFerla FM.PLoS One. 2014 Sep 3;9(9):e106009. doi: 10.1371/journal.pone.0106009. eCollection 2014.PMID: 25184527 

Impact of hippocampal neuronal ablation on neurogenesis and cognition in the aged brain.

Yeung ST*, Myczek K*, Kang AP, Chabrier MA, Baglietto-Vargas D, Laferla FM.Neuroscience. 2014 Feb 14;259:214-22. doi: 10.1016/j.neuroscience.2013.11.054. Epub 2013 Dec 4.PMID: 24316470

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